Hentet- NRK: https://www.nrk.no/trondelag/forsker-ved-ntnu-dyrket-minihjerner-og-fant-arsaken-til-sjeldne-syndrom-1.15512134
Dyrket minihjerner og fant nøkkelen til uvanlige syndrom
NTNU-forsker fant at flere sjeldne diagnoser har en felles årsak. «Skurken» er også kjent for å forårsake kreft.
Foreldre som får barn med alvorlige syndrom, sitter ofte igjen med ubesvarte spørsmål. Det kan være vanskelig å finne god informasjon, da diagnosene er sjeldne.
En av dem som forsøker å hjelpe, er professor Barbara van Loon ved NTNU. Hun forsker på DNA-reparasjon. Ved å studere celler i kroppen leter hun etter svar på hvordan ting henger sammen.
Nå har forskeren i Trøndelag oppdaget viktig nytt.
Et protein, kalt p53, er kjent i forbindelse med ulike kreftsvulster. Nå viser det seg at det samme proteinet også er årsaken til en rekke sjeldne syndrom.
– Funnet vårt betyr ikke at vi kan komme med en kur før jul, men det kan være et grunnlag for behandling i framtiden, sier forskeren til NRK.
Live (5) har sjelden sykdom
Live Moa fra Overhalla er snart fem år. Hun har, som en av to i Norge, den sjeldne sykdommen kalt Succinat-Semi-Aldehyd-Dehydrogenase-Mangel (SSADH-mangel).
Det er rundt 400 mennesker som har den sjeldne genfeilen på verdensbasis.
Mamma Kine Renate Johansen mener noe av det aller verste er å leve i uvitenhet.
– Det å få svar er så viktig. Det er ingen som kan planlegge hva framtiden bringer, men det er jo naturlig at barna dine blir konfirmert, flytter ut og får egen familie. Vi vet ikke engang om Live vil passere 10-årsalderen mentalt, sier hun til NRK.
Mammaen setter stor pris på at det er noen som forsker på området.
Dyrket minihjerner
Det er utfordrende å forske på de sjeldne diagnosene, siden få er rammet av nøyaktig det samme. Dette fører til at sammenligningsgrunnlaget blir smalt, forklarer professor van Loon.
Derfor valgte hun å sammenligne flere syndrom med mutasjoner i samme gen.
– Hver for seg er de sjeldne og få, men hvis man slår dem sammen, er mange mennesker rammet.
Professoren hentet derfor inn blodceller fra fem gutter med sjeldne syndrom, slik at genmaterialet var stort nok til å lete etter en sammenheng.
For å gjenskape sykdomsutviklingen, dyrket van Loon fram minihjerner i laboratoriet.
Dette klarte hun ved å lage stamceller fra hudceller. Ei stamcelle er en celle som kan fornye seg, og som har evnen til å lage mange ulike typer celler og vev. Den kan også omprogrammeres.
Etter åtte års arbeid kom gjennombruddet.
Synderen
Synderen er altså proteinet p53, som er avgjørende for grunnleggende nevrologiske mekanismer i kroppen vår.
Det er allerede kjent at manglende p53 er involvert i utvikling av kreft. Nå er det for første gang dokumentert at dette proteinet (ukontrollert) også kan føre til store skader på hjernens utvikling.
Dette er grunnen til at barn får syndrom med omfattende konsekvenser, forteller NTNU-professoren.
Hun sier det mest gledelige med funnet er at familier får nye svar.
– Det er viktig å gi noe tilbake. Vi er helt avhengige av donorer for å forske på de sjeldne syndromene, og nå gir vi ny informasjon i retur.
Opplever ofte at legene ikke har peiling på sykdommen hans
Møter foreldre som føler skyld
Marte Gjøl Haug er overlege i medisinsk genetikk ved St. Olavs hospital. Hun møter ofte foreldre som har barn med sjeldne genfeil.
Overlegen sier de har sett en økning i henvisninger de siste årene, fordi genetisk testing har blitt billigere og lettere tilgjengelig.
Foreldre er ofte bekymret for at det er deres feil at barnet er født med alvorlige defekter. Mange foreldre sliter med skyldfølelse, forklarer Haug.
– De som har gått lenge i uvisshet har nok hatt noen tanker om hvorfor ting ble som det ble, og dette er tanker vi kan «avlive» med en genetisk test. Mange frykter jo at noen få enheter med alkohol under svangerskapet kan være årsaken til sykdommen, mens andre frykter arbeidsrelaterte sammenhenger. Det kan være folk som har jobbet med kjemikalier.
Når de får vite at syndromet skyldes skader på et gen, blir mange veldig lettet, forteller overlegen.
Hun mener funnet ved NTNU er viktig.
– Det er gjennom pasientene vi lærer spekteret av tilstander, men forskerne kan ta denne informasjonen et hakk videre. Det å finne de biologiske nøklene er helt avgjørende, sier Gjøl Haug til NRK.
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Almanya’nın en iyi medyumu haluk hoca sayesinde sizlerde güven içerisinde çalışmalar yaptırabilirsiniz, 40 yıllık uzmanlık ve tecrübesi ile sizlere en iyi medyumluk hizmeti sunuyoruz.
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Almanya’nın en çok tercih edilen medyumu haluk yıldız hoca olarak bilinmektedir, 40 yıllık tecrübesi ile sizlere en iyi bağlama işlemini yapan ilk medyum hocadır.
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Merhaba Ben Haluk Hoca, Aslen Irak Asıllı Arap Hüseyin Efendinin Torunuyum. Yaklaşık İse 40 Yıldır Havas Ve Hüddam İlmi Üzerinde Sizlere 100 Sonuç Veren Garantili Çalışmalar Hazırlamaktayım, 1964 Yılında Irak’ın Basra Şehrinde Doğdum, Dedem Arap Hüseyin Efendiden El Aldım Ve Sizlere 1990 lı Yıllardan Bu Yana Medyum Hocalık Konularında Hizmet Veriyorum, 100 Sonuç Vermiş Olduğum Çalışmalar İse, Giden Eşleri Sevgilileri Geri Getirme, Aşk Bağlama, Aşık Etme, Kısmet Açma, Büyü Bozma Konularında Garantili Sonuçlar Veriyorum, Başta Almanya Fransa Hollanda Olmak Üzere Dünyanın Neresinde Olursanız Olun Hiç Çekinmeden Benimle İletişim Kurabilirsiniz.
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Almanya’nın en iyi güvenilir medyumunun tüm sosyal medya hesaplarını sizlere paylaşıyoruz, güvenin ve kalitelin tek adresi olan medyum haluk hoca 40 yıllık uzmanlığı ile sizlerle.
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Dünyaca ünlü medyum haluk hocayı sizlere tanıtıyoruz anlatıyoruz, Avrupanın ilk ve tek medyum hocası 40 yıllık uzmanlık ve tecrübesi ile sizlerle.
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Dünyaca ünlü medyum haluk hocayı sizlere tanıtıyoruz anlatıyoruz, Avrupanın ilk ve tek medyum hocası 40 yıllık uzmanlık ve tecrübesi ile sizlerle.
Belçika’nın en iyi medyumu medyum haluk hoca ile sizlerde en iyi çalışmalara yakınsınız, hemen arayın farkı görün.
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Medyum haluk hoca avrupanın en güvenilir medyum hocasıdır, sizlerinde bilgiği gibi en iyi medyumu bulmak zordur, biz sizlere geldik.
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Ünlülerin tercih ettiği medyum hocamıza dilediğiniz zaman ulaşabilirsiniz, medyum haluk hocamız sizlerin daimi yanında olacaktır.
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Birincisi güvenilir medyum hocaları bulmak olacaktır, ikinci seçenek ise en iyi medyumları bulmak olacaktır, siz hangisini seçerdiniz.
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Dünyaca ünlü medyum haluk hoca, 40 yıllık uzmanlık ve tecrübesi ile sizlere en iyi hizmetleri vermeye devam ediyor, Aşk büyüsü bağlama büyüsü giden sevigiliyi geri getirme.
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Ünlülerin tercihi medyum haluk hoca sizlerle, en iyi medyum sitemizi ziyaret ediniz.
Ünlülerin tercihi medyum haluk hoca sizlerle, en iyi medyum sitemizi ziyaret ediniz.
In my opinion that a foreclosed can have a major effect on the applicant’s life. Mortgage foreclosures can have a 7 to a decade negative affect on a applicant’s credit report. The borrower who may have applied for home financing or any kind of loans as an example, knows that the actual worse credit rating can be, the more difficult it is to acquire a decent bank loan. In addition, it could possibly affect any borrower’s capacity to find a good place to lease or rent, if that becomes the alternative housing solution. Good blog post.
Ünlülerin tercihi medyum haluk hoca sizlerle, en iyi medyum sitemizi ziyaret ediniz.
Ünlülerin tercihi medyum haluk hoca sizlerle, en iyi medyum sitemizi ziyaret ediniz.
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Ünlülerin tercih ettiği bir medyum hoca bulmak o kadarda zor değil, medyum haluk hoca sizlerin en iyi medyumu.
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Güvenilir bir medyum için bizi tercih ediniz, medyum haluk hocamız sizler için elinden geleni yapıyor.
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En iyi medyumu arıyorsanız hiç çekinmeden medyum hocamızı ziyaret edebilir ve kendisinden bizzat destek alabilirsiniz.
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Almanya köln medyumu haluk yıldız hoca sizlere ne iyi medyum hizmeti veriyor…
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Avrupa’nın en güvenilir medyum hocalarından medyum haluk yıldız hocamız siz değerli kardeşlerimize yardım eli uzatıyor.
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Avrupa’nın en iyi tanınan medyum hocalarından medyum haluk yıldız hocamız siz değerli kardeşlerimize yardım eli uzatıyor.
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Tütsüler hakkında bilinmeyen ne varsa sizlerle en güzel yorumları tütsü çeşitleri sizlerle.
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Healthcare Blog provides news, trends, jobs and resources for health industry professionals. We cover topics like healthcare IT, hospital administration, polcy
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